As with other μ-opioid agonists, tapentadol may cause spasms of the sphincter of Oddi, and is particularly for that reason discouraged for use in patients with biliary tract disease for instance both equally acute and Persistent pancreatitis. People who are immediate or ultra swift metabolizers to the CYP2C9, CYP2C19, and CYP2D6 enzymes may well n… Read More